Skin Test Detects Parkinson’s and Other Synucleinopathies
Skin biopsies detected phosphorylated alpha-synuclein in a high proportion of people with Parkinson’s disease and other synucleinopathies. Finding a reliable diagnostic biomarker for synucleinopathies is an urgent unmet need. Further research is needed in other clinical populations to validate these findings. Skin biopsies detected cutaneous phosphorylated alpha-synuclein (p-syn) in a high proportion of people who […]
Alzheimer’s Blood Test Predicts Who Might Benefit Most From Anti-Amyloid Drugs
Plasma phosphorylated tau 217 (p-tau217) outperformed p-tau181, p-tau231, and other blood-based biomarkers to identify which patients might benefit most from anti-amyloid Alzheimer’s drugs, a cohort study showed. Plasma p-tau217 helped rule out two groups who would not likely benefit: those who were amyloid-negative, and those who were amyloid-positive but had a high tau burden, reported […]
Blood Test Discerns Alzheimer’s From Other Dementia With High Accuracy
Two blood markers, phosphorylated tau 217 (p-tau217) and phosphorylated tau 181 (p-tau181), showed strong diagnostic performances for Alzheimer’s disease and discriminated Alzheimer’s from frontotemporal lobar denervation (FTLD) syndromes and normal cognition, a retrospective study showed. Both plasma biomarkers distinguished Alzheimer’s disease syndromes from non-Alzheimer’s disease disorders with a receiver operating characteristic area under the curve […]