Neurologic Conditions Now Leading Cause of Disability Worldwide
Disorders affecting the nervous system were the leading cause of ill health and disability globally, affecting 3.4 billion people worldwide, a systematic analysis for the Global Burden of Disease (GBD) Study showed. Neurologic conditions affected 43.1% of the world’s population and were the top contributor to the global disease burden in 2021, ahead of cardiovascular […]
Clinical Challenges: Secondary CNS Relapse in Diffuse Large B-Cell Lymphoma
Central nervous system (CNS) relapse occurs in roughly one in 20 patients with diffuse large B-cell lymphoma (DLBCL), but in some disease subtypes that risk increases substantially. “In certain subsets of patients, the risk is quite low, but in others it can be quite high so it is better to focus on the high-risk groups,” […]
Muscle biopsy test for biomarker could lead to earlier diagnosis of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive disease of the nervous system. It affects nerve cells in the brain and spinal cord called motor neurons. Motor neurons control muscle movement and ALS causes them to deteriorate and eventually die. The motor neurons lose the ability to send messages to the muscles in the body, affecting […]
Microglial methylation ‘landscape’ in human brain: Profiles differ across age, disease state, brain region
In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states. But the molecular mechanisms that contribute to these transcriptomic changes in the human brain are […]
7 Signs Of A Nervous Breakdown
By Rosie McCall I’m having a nervous breakdown. You may utter this (or at least think it) when you’re overwrought and ready to snap. But what is a nervous breakdown, exactly? And what should you do when you feel like you’re about to fall apart? Advertisement It turns out “nervous breakdown” isn’t a clinical term. […]