KRAS Mutations in Metastatic CRC Predict Survival Benefit of Chemo Combo
Codon-specific KRAS mutations are predictive of an overall survival (OS) benefit for metastatic colorectal cancer (mCRC) patients treated with trifluridine-tipiracil (FTD/TPI; Lonsurf), according to a genomics-based analysis. After identifying biomarkers of resistance and validating the findings in a real-world dataset, researchers showed that patients with KRAS G12-mutant tumors in the phase III RECOURSE trial achieved […]
New model helps identify mutations that drive cancer: The system rapidly scans the genome of cancer cells, could help researchers find targets for new drugs.
Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride. Distinguishing these harmful driver mutations from the neutral passengers could help researchers identify better drug targets. To boost those efforts, an MIT-led team has built […]
Opinion | Our Lab Testing Capacity Is Getting Dangerously Low
Continued mutations in SARS-CoV-2 mean new and emerging variants, a sign that COVID-19 isn’t going away anytime soon, despite a relaxing of public health measures around the country. And due to the increased availability of at-home antigen-based testing, published case counts are likely being underreported by public health officials, making a COVID-19 resurgence more difficult […]