Combination Shows Promise in Metastatic ESR1-Mutant Breast Cancer
A novel drug combination led to clinically meaningful antitumor activity in metastatic ESR1-mutated, estrogen receptor-positive (ER+)/HER2-negative breast cancer that had progressed on CDK4/6 inhibition, a small prospective study showed. Adding the selective estrogen receptor modulator (SERM) lasofoxifene to abemaciclib (Verzenio) resulted in a median progression-free survival (PFS) of 56 weeks, and a 24-week clinical benefit […]
Novel Anti-HER2 Drugs ‘Impressive’ in Advanced Biliary Cancer
CHICAGO — In a pair of mid-stage trials, newer targeted therapies demonstrated meaningful levels of activity against HER2-positive biliary tract cancers in pretreated patients with advanced disease. Cohort 1 of the global HERIZON-BTC-01 study, which included 80 treatment-refractory patients, showed that 41.3% (95% CI 30.4-52.8) responded to zanidatamab, an investigational bispecific monoclonal antibody that targets […]
Leading Through Crisis at the WHO
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe/follow on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. When COVID-19 rapidly emerged, the World Health Organization (WHO) was thrust into an unprecedented challenge. The global […]
Thriving After Cancer
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe/follow on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. When we hear about people with cancer, the stories often end when the treatments end — either […]
Leading Healthcare Through Relationships
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. What does it take to lead a health department with a budget of more than $50 billion, […]
Life Lessons From Death
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. “Death is not waiting for us at the end of a long road. Death is always with […]
Love and Mercy in the ICU
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. The ICU can be a traumatizing place for patients, who are frequently heavily sedated, rendered unable to […]
On Vision and the Arts
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. Few would dispute that vision is just about our most important sense. At least from a neurophysiological […]
Confronting Inhumanity Through Medicine
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. When it comes to medical humanitarianism, there is no bigger name than Médecins Sans Frontières (MSF), also […]
On Moral Injury and Emotions in Medicine
“The Doctor’s Art” is a weekly podcast that explores what makes medicine meaningful, featuring profiles and stories from clinicians, patients, educators, leaders, and others working in healthcare. Listen and subscribe on Apple, Spotify, Amazon, Google, Stitcher, and Podchaser. As one of the most prolific and acclaimed physician-writers today, Danielle Ofri, MD, is the author of […]