Mahvash Disease Case Resolved With Liver Transplantation
A woman with Mahvash disease presented with portal hypertension that necessitated liver transplantation; the liver complications observed in this case report distinguish it from what’s more typically seen in patients with this condition. The 27-year-old woman presented with mildly elevated aminotransferase levels and chronic pancreatitis after having experienced three episodes of hematemesis. Although her imaging […]
Mahvash Disease Case Resolved With Liver Transplantation
A woman with Mahvash disease presented with portal hypertension that necessitated liver transplantation; the liver complications observed in this case report distinguish it from what’s more typically seen in patients with this condition. The 27-year-old woman presented with mildly elevated aminotransferase levels and chronic pancreatitis after having experienced three episodes of hematemesis. Although her imaging […]
Two probiotics identified as promising hypertension treatments
An estimated 40% of the global adult population have high blood pressure, or hypertension, which puts people at risk of cardiovascular disease and other dangerous health conditions. Recent studies suggest that probiotics may offer a protective effect, but researchers have a limited understanding of why shaping the gut microbiota can regulate blood pressure. A study […]
Lorundrostat Stands a Chance Against Obesity-Related Hypertension
Among selected people with uncontrolled hypertension, blood pressure (BP) could be successfully reduced with a highly selective aldosterone synthase inhibitor, a phase II dose-finding trial found. In hypertensive patients with suppressed renin — theoretically the group most likely to benefit from reining in aldosterone production — reductions of automated office systolic BP reached up to […]
Medtronic’s Renal Denervation System for Hypertension Splits FDA Panel
A radiofrequency-based renal denervation system for uncontrolled hypertension got a cool reception from FDA advisors who nevertheless left the door open for regulatory approval. On Wednesday, the FDA’s Circulatory System Devices Panel voted 6-7 (with one abstention) that the benefits of the Symplicity Spyral multi-electrode catheter system do not outweigh its risks when used to […]
‘Exciting’ siRNA Therapy for Hypertension Passes First Hurdle
Patients with hypertension successfully dialed down their angiotensinogen levels and had lasting reductions in blood pressure (BP) following one injection of an investigational small interfering RNA (siRNA) therapy, according to a phase I study. In this first-in-human, placebo-controlled study, patients who received zilebesiran showed dose-dependent decreases in serum angiotensinogen levels and 24-hour ambulatory BP after […]
Genetic Risk Score Predicts Hypertensive Disorders of Pregnancy
With new genetic variants identified for preeclampsia and gestational hypertension, researchers created polygenic risk scores (PRS) that may better identify candidates for prophylactic low-dose aspirin among pregnant mothers. There were 18 independent genetic loci significantly associated with hypertensive disorders of pregnancy (HDPs) — 12 of them new (i.e., MTHFR-CLCN6, WNT3A, NPR3, PGR, and RGL3) — […]
Pharmacist-Led Hypertension Clinics Able to Lower BP Within Weeks
SAN DIEGO — Across the country, nurse- and pharmacist-led hypertension clinics consistently found it feasible to get blood pressures (BPs) at or close to goal quickly — within a matter of weeks, even — according to single-center reports. In posters presented here at the annual Hypertension Scientific Sessions hosted by the American Heart Association, researchers […]
Arterial stiffness raises blood pressure in adolescents via insulin resistance
In the young population, arterial stiffness, an emerging risk factor for hypertension, indirectly raises blood pressure via an increase in insulin resistance but not via an increase in body fat, a paper published in Frontiers in Cardiovascular Medicine concludes. There is a global effort aimed at screening, identification, and early diagnosis of hypertension in order […]
Do COVID Vaccines Stave Off New Medical Conditions?
Risks of long COVID symptoms and the incidence of new onset hypertension, diabetes, and heart disease were lower among vaccinated patients with breakthrough infection versus those with COVID who were unvaccinated, a large analysis of medical records in the U.S. suggested. Compared to those who were unvaccinated, relative risks were 0.33 for hypertension (95% CI […]