No Increased Breast Cancer Risk With Menopausal Estrogen in BRCA Carriers
SAN ANTONIO — Menopausal hormone therapy (MHT) did not increase breast cancer risk in women with BRCA mutations, according to a study reported here. In fact, women who used estrogen-only MHT had a significantly lower risk of breast cancer compared with a matched cohort of women who did not use MHT (42.% vs 24.9%). An […]
Clinical Challenges: Beyond CDK4/6 Inhibition in Advanced HR-Positive Breast Cancer
The emergence of CDK4/6 inhibitors has reshaped the therapeutic landscape for advanced hormone receptor (HR)-positive breast cancer, extending progression-free survival (PFS) and in some cases overall survival (OS) when combined with first-line endocrine therapy. Unfortunately, most patients eventually progress, and the next step after CDK4/6 inhibition is perhaps “the hottest topic that all of us […]
Sharp Uptick in Gender-Affirming Hormone Therapy Visits After ACA’s Passage
Healthcare visits for transgender-related diagnoses and gender-affirming hormone therapy (GAHT) have been rising, researchers reported, suggesting it as an opportunity for HIV prevention. Within a commercial health plan database, the proportion of adults with a transgender-related diagnosis code increased by 30.8% each year from 2014 to 2021 (13.4 to 113.9 per 100,000 enrolled persons) for […]
Is Omitting Radiation Therapy in Low-Risk Breast Cancer a Good IDEA?
SAN ANTONIO — Postmenopausal women with genomically low-risk early hormone receptor (HR)-positive breast cancer had a low risk of recurrence with endocrine therapy alone after lumpectomy, a randomized trial showed. The 5-year overall survival (OS) and cancer-specific survival (CSS) rates were 100% without adjuvant radiation therapy (RT) in 186 women ages 50-69 followed for at […]
Hunger hormones impact decision-making brain area to drive behavior
A hunger hormone produced in the gut can directly impact a decision-making part of the brain in order to drive an animal’s behaviour, finds a new study by UCL (University College London) researchers. The study in mice, published in Neuron, is the first to show how hunger hormones can directly impact activity of the brain’s […]
Studies Question Role of CDK4/6 Inhibitors in First-Line Advanced Breast Cancer
CHICAGO — Upfront CDK4/6 inhibition or second-line use in advanced hormone receptor (HR)-positive/HER2-negative breast cancer led to similar cumulative progression-free survival (PFS) in a large randomized trial. Patients who received a CDK4/6 inhibitor plus an aromatase inhibitor (AI) as initial therapy and fulvestrant in the second line had a median PFS of 31.0 months at […]
What Drives Alzheimer’s in Women?
Female sex, early age at menopause, and hormone therapy use each were associated with higher regional tau in cognitively normal people with elevated beta-amyloid, cross-sectional PET data showed. The highest levels of tau were seen in hormone therapy users who had a delay of more than 5 years between menopause onset and the start of […]
Escalated ADT Falls Short in Men With High-Risk Features After Prostatectomy
SAN FRANCISCO — Add-on hormone therapy plus an antiandrogen to salvage radiation and androgen deprivation therapy (ADT) did not boost survival outcomes in high-risk prostate cancer. In the FORMULA-509 trial, the addition of 6 months of abiraterone acetate (Zytiga) and apalutamide (Erleada) to salvage radiation (RT) and 6 months of ADT with a GnRH agonist […]
Hormone Infusion Shows Promise for Low Sexual Desire
An infusion of the hormone kisspeptin helped improve low sexual desire in both men and women, two small trials found. In the 37-participant study of heterosexual men with hypoactive sexual desire disorder (HSDD), IV kisspeptin-54 significantly increased activity in key sexual-processing structures of the brain in response to viewing sexual videos compared with placebo (mean […]
Online Gender-Affirming Services Can Be Appealing, Though Often Don’t Take Insurance
MIAMI — Some telemedicine companies offering gender-affirming hormone treatment offered an affordable alternative to traditional care models, a researcher reported at the Sexual Medicine Society of North America (SMSNA) annual meeting. A review of available services from six direct-to-consumer platforms — Folx Health, True U Clinic, QueerDoc, Q, TransClinique, and Plume — found that all […]