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ADC-Pertuzumab Promising as New Standard in HER2-Positive Metastatic Breast Cancer

CHICAGO — First-line trastuzumab deruxtecan (T-DXd) combined with pertuzumab (Perjeta) improved progression-free survival (PFS) in HER2-positive locally advanced or metastatic breast cancer, according to the DESTINY-Breast09 trial. In the phase III study after a median of follow-up of 29 months, patients randomized to T-DXd plus pertuzumab had a median PFS by blinded independent central review […]

Alternative Endpoints in Phase III Trials Don’t Always Mean Boosts to OS, QOL

CHICAGO — Late-phase trials that showed superiority for an experimental intervention on a surrogate endpoint did not necessarily lead to improvements in overall survival (OS) or quality of life (QOL), according to a meta-epidemiologic analysis. Alexander Dean Sherry, MD of the MD Anderson Cancer Center in Houston, and colleagues evaluated 791 randomized controlled trials (RCTs) […]

A Chicago Hospital Bows to Federal Pressure on Trans Care for Teens

He’s 17 and lives in the Chicago suburbs. He loves theater and recently helped direct a play at his high school. He takes competitive AP courses and is working on his Eagle Scout project. And he’s been on a journey for 4 years. Once a week, the transgender teen injects testosterone into his body. He’s […]

Potent Benzodiazepine Masquerading as Xanax Hospitalizes Three in Chicago

Three young adults in Chicago who thought they were taking alprazolam (Xanax) actually ingested the unapproved and far more potent bromazolam, requiring an intensive care unit stay, public health officials warned. The “designer” benzodiazepine derivative that was synthesized in 1976 but never approved for therapeutic use has been on the rise across the world and […]

Common Headaches May Be Pains in the Neck

CHICAGO — Inflammation and edema of the trapezius muscles appeared linked to tension and migraine headaches, a small prospective cohort study found. Patients with mixed-type tension and migraine headaches demonstrated the highest muscle T2 MRI values (31.4 ms on the right and left sides), and the average value was significantly higher compared to those with […]

Wide Variation in CGM Settings for Kids With Diabetes Signals Education Gaps

CHICAGO — Kids using continuous glucose monitors (CGMs) to manage their diabetes often do not have settings in place to alert them and their caregivers about out-of-range sugar levels, suggesting possible gaps in education and onboarding, real-world data showed. In a study that included 150 children and teenagers using CGMs for their type 1 or […]

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