Thalidomide Reduced Episodes of Recurrent GI Bleeding
Treatment with thalidomide led to a reduction in bleeding among patients with recurrent bleeding due to small-intestinal angiodysplasia (SIA), a randomized trial showed. In 150 patients, 68.6% of those who received 100-mg thalidomide daily for 4 months experienced a reduction of 50% or more in bleeding episodes in the year after treatment compared with 51% […]
Scattered Brain Bleeds, Vasculitis in Alzheimer’s Trial Death
A fatal bleeding event in an Alzheimer’s clinical trial participant may have been linked with the investigational anti-amyloid agent lecanemab, a case report suggested. However, drug trialists are not willing to assign blame yet, especially as lecanemab’s fate hangs in a potential FDA approval for early Alzheimer’s disease later this week. Information about the case […]
FDA OKs First Gene Therapy for Hemophilia B
The FDA on Tuesday approved the first gene therapy for treating hemophilia B, a genetic bleeding disorder resulting from missing or insufficient levels of factor IX. Etranacogene dezaparvovec (Hemgenix) is indicated for adults with the condition who currently use factor IX prophylaxis therapy for blood clotting, those who have or have had life-threatening hemorrhage, or […]
Making Low-Dose tPA Work for Japanese DOAC Users With Ischemic Stroke
Despite concerns about the potential bleeding risk, IV thrombolysis could be safely given to ischemic stroke patients within a day of direct oral anticoagulant (DOAC) therapy, according to observational data from Japan. Between DOAC users and peers not taking oral anticoagulants within 48 hours of stroke onset, rates of symptomatic intracranial hemorrhage, accompanied by a […]
Several Factors Contribute to GI Bleeding Mortality Risk
Patients who developed upper gastrointestinal (GI) bleeding during a hospital stay experienced worse adverse outcomes than those admitted for upper GI bleeding alone, French researchers found in a prospective study. Currently hospitalized patients (dubbed “inpatients”) with upper GI bleeding showed a significantly higher mortality rate at 6 weeks than patients hospitalized for GI bleeding alone […]