Obesity disrupts normal liver function in mice
Your liver plays a vital role in your metabolism, the biological process which converts food into energy. We know that being overweight can negatively affect metabolic activity, but not exactly how. To better understand this, researchers compared the livers of mice which were a typical weight with mice which were obese. They were surprised to […]
Calorie restriction in humans builds strong muscle and stimulates healthy aging genes
Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in […]
Why obesity is more dangerous for men: Building blocks of blood vessels found to be associated with inflammation and disease processes in male mice
A newly published study from York University sheds light on the biological underpinnings in sex differences in obesity-related disease, with researchers observing “striking” differences in the cells that build blood vessels in the fatty tissue of male versus female mice. Men are more likely than women to develop conditions associated with obesity such as cardiovascular […]
Researchers feed worms a natural plant extract; watch them fatten, live 40% longer
A research team in the Louisiana State University Department of Biological Sciences led by Assistant Professor Adam Bohnert has published a landmark study linking greater metabolic health — achieved through a natural plant extract — with longer lifespans in C. elegans, commonly known as roundworms. Although worms and humans don’t appear to have much in […]
Antibody with engineered peptide targets bone metastasis: Enhanced breast cancer drug could halt spread
A moderate amount of a peptide-enhanced, biological cancer drug goes a long way in treating breast cancers that metastasize to the bone. A study by scientists at Rice University and Baylor College of Medicine demonstrated the effective treatment of such cancers in rodent models, bringing hope for new therapies to treat bone metastases. The open-access […]
For stem cells, bigger doesn’t mean better
MIT biologists have answered an important biological question: Why do cells control their size? Cells of the same type are strikingly uniform in size, while cell size differs between different cell types. This raises the question of whether cell size is important for cellular physiology. The new study suggests that cellular enlargement drives a decline […]
Blood metabolites associated with coffee consumption may affect kidney disease risk
Food and beverages may have important effects on kidney health, but the potential biological mechanisms involved are often unclear. New research in CJASN identifies several metabolites in the blood whose levels are altered by coffee consumption and may affect the risk of developing chronic kidney disease (CKD). When Casey M. Rebholz, PhD, MS, MNSP, MPH […]