Novel CAR-T for Glioblastoma Induced ‘Dramatic’ Responses in Early Trial
A new approach to chimeric antigen receptor (CAR) T-cell therapy showed promise in treating recurrent glioblastoma, according to a small phase I study. In the first-in-human trial, three patients with recurrent glioblastoma who were treated with CARv3-TEAM-E T cells experienced “dramatic and rapid” tumor regression within days of receiving a single intraventricular infusion, reported Marcela […]
Low-Dose Intradermal Mpox Vaccine on Par With Subcutaneous Dosing
Mpox vaccination with a two-shot, low-dose intradermal approach produced similar antibody titers levels compared with the standard subcutaneous dosing regimen, an observational study showed. Two 0.1-mL intradermal doses of the modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine yielded geometric mean titers of immunoglobulin G (IgG) antibodies that neutralize mpox of 88.65 (95% CI 48.09-163.42), compared with […]
Is Electrical Duodenal Resurfacing the Next Big Thing for T2D and Obesity?
CHICAGO — A novel approach to revitalizing the duodenal mucosa as a means to restore normal insulin sensitivity in people with type 2 diabetes is showing strong promise in early studies, according to results presented here. In two single-arm trials of a system called ReCET, reported at Digestive Disease Week (DDW), patients with either poorly […]
Trial: Functional Scoring a Better Guide to Neonatal Opioid Withdrawal Tx
A newer function-based approach to treating neonatal opioid withdrawal syndrome safely readied babies to go home sooner, the ACT NOW randomized trial showed. With the Eat, Sleep, Console care approach, time from birth to medical readiness for hospital discharge by American Academy of Pediatrics-endorsed standards was nearly a week sooner than when treating guided by […]
America’s Loneliness Epidemic Is Fueling The Far Right, Sen. Chris Murphy Says
Sen. Chris Murphy (D-Conn.) is a mainstream progressive known for supporting a tougher U.S. approach to Saudi Arabia and stricter gun safety regulations. In December, though, he began taking up a cause not typically on Congress’ agenda: an epidemic of loneliness in the United States that Murphy believes is quietly at the heart of the […]
MedPAC Considers Reference Pricing and Other Ideas for Cutting Part B Drug Costs
Congress will need to use a multipronged approach to bring down prescription drug costs in the Medicare Part B program, members of the Medicare Payment Advisory Commission (MedPAC) agreed at their March meeting on Thursday. MedPAC members discussed three draft recommendations being considered for inclusion in the commission’s June report to Congress. The recommendations addressed […]
Opinion | Here’s How States Should Use the Opioid Settlement Funds
On August 16, 2022, Sarah Wakeman, MD, shared her perspective on how the U.S. is taking the wrong approach to addressing the drug overdose crisis. As part of MedPage Today‘s review of the past year’s top events, Wakeman follows up with her thoughts on how states can correct the current failing approach and best use […]
Funding, Policy Changes Needed to End Maternal Health Crisis, Federal Officials Say
WASHINGTON — Addressing the maternal mortality crisis requires a layered approach that includes extending Medicaid coverage for postpartum persons, expanding home visitation programs, and giving hospitals “gold stars,” government officials said. But without action from Congress and the states, they stressed during a stakeholder meeting here Tuesday, certain tools to reduce maternal illness and death […]
New insights on how some individuals with obesity can lose weight — and keep it off
For decades, there’s been a persistent one-size-fits-all approach to treating obesity: Embrace a diet that’s low in calories. Yet evidence shows that this diet-focused approach simply doesn’t work for a subset of adults with obesity who are adherent in a clinical weight management program. Now, compelling new research published in the journal eBioMedicine challenges the […]
No more binge eating: Signal pathway in the brain that controls food intake discovered
A group of researchers has developed an entirely novel approach to treating eating disorders. The scientists showed that a group of nerve cells in the hypothalamus (so-called AgRP, agouti-related peptide neurons) control the release of endogenous lysophospholipids, which in turn control the excitability of nerve cells in the cerebral cortex, which stimulates food intake. In […]