DEAR DR. ROACH: I have always wondered if it matters if you swallow a bunch of pills in one swallow or if it would be better to space them out. I take a bunch, like Eliquis, dicyclomine, gabapentin, etc. — B.A.

ANSWER: With most pills, it’s OK to take them as a bunch together, if you can tolerate doing so (I’ve known people who have a tough time taking multiple pills at the same time due to gagging). There are a few combinations of pills that shouldn’t be taken together, such as tetracyclines and calcium, but these should be labelled clearly on your bottle. A few medicines, like alendronate (Fosamax), can’t be taken with any other medicines. Some medicines, including all the ones you mentioned, can cause sedation, which can be worse if taken together.