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Supreme Court Appears Skeptical of Challenge to Abortion Pill Access

The Supreme Court seemed likely to preserve access to the widely used abortion pill mifepristone (Mifeprex), in the court’s first abortion case since it overturned Roe v. Wade 2 years ago. During oral arguments on Tuesday, justices appeared skeptical of the plaintiffs’ case for a lawsuit that questions whether the FDA overlooked safety concerns when […]

JAK Inhibitor Preserves Beta-Cell Function in Early Type 1 Diabetes

A Janus kinase (JAK) inhibitor helped preserve beta-cell function in people with recent-onset type 1 diabetes, the phase II BANDIT trial found. Meeting the study’s primary endpoint, daily baricitinib (Olumiant) maintained a significantly higher average mixed-meal-stimulated C-peptide level at week 48 compared with placebo (0.65 vs 0.43 nmol/L/min, P=0.001), according to Thomas Kay, MBBS, PhD, […]

Antibody Slows Beta-Cell Loss Early in Type 1 Diabetes

A course of teplizumab (Tzield) may help preserve beta-cells when given early after a type 1 diabetes (T1D) diagnosis, similar to the anti-CD3 antibody’s delay on progression from preclinical disease, the randomized PROTECT trial showed. Two 12-day courses of the drug resulted in 59.3% less loss of beta-cell function, with higher stimulated C-peptide levels at […]

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