Linezolid ‘Not Recommended’ to Treat Early Syphilis
Linezolid failed to meet noninferiority criteria when compared with standard benzathine penicillin G (BPG) in the treatment of early syphilis, according to findings of the randomized, controlled Trep-AB Study of cisgender men. Only 70% of trial participants with early syphilis who were treated with linezolid were cured, compared with 100% of participants treated with penicillin, […]
Few Early Alzheimer’s Patients Qualify for Lecanemab
Few people with early Alzheimer’s disease met eligibility criteria for the new anti-amyloid monoclonal antibody treatments lecanemab (Leqembi) and aducanumab (Aduhelm), cross-sectional data from the Mayo Clinic Study of Aging showed. Of 237 people with mild cognitive impairment or mild dementia and increased brain amyloid on PET, clinical trial inclusion and exclusion criteria narrowed the […]
Pre-COPD Current and Former Smokers Not in the Clear for Airway Disease
Whether they had respiratory symptoms or not, former and current smokers who didn’t meet criteria for chronic obstructive pulmonary disease (COPD) had similar declines in lung function and progression to COPD in subsequent years, the SPIROMICS II study found. Participants with symptomatic tobacco exposure and preserved spirometry (TEPS) experienced no significant difference in annual declines […]
Adding This New Criteria Drastically Cut 72-Hour Insulinoma Fast Time
SEATTLE — Adding beta-hydroxybutyrate (BHB) stopping criteria cut down fasting time when detecting insulinomas in patients with hypoglycemia, according to late-breaking findings presented here. By adding in a stopping point if BHB reached a level of 2.7 mmol/L or higher to the fasting protocol, fasting time was nearly 8 hours shorter on average across the […]
Liver Toxicity in Gene Therapy Trials Could Merit Stricter Entry Criteria
An FDA advisory committee offered up lower vector doses, stricter exclusion criteria, and long-term animal studies to grapple with liver toxicities associated with adeno-associated virus (AAV) vector-based gene therapies. During the second of four sessions on AAV safety, the Cellular, Tissue, and Gene Therapies Advisory Committee (CTGTAC) weighed evidence of hepatotoxicity — ranging from liver […]